A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer

Some gastric cancers have FGFR2 amplifications, making them sensitive to FGFR inhibitors. However, cancer cells inevitably develop resistance despite initial response. The underlying resistance mechanism to FGFR inhibition is unclear. In this study, we applied a kinome-wide CRISPR/Cas9 screen to sys...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Chen, Jiamin, Bell, John, Lau, Billy T., Whittaker, Tyler, Stapleton, Darren, Ji, Hanlee P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510732/
https://ncbi.nlm.nih.gov/pubmed/31076567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-019-0145-z
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