CRISPR-Cas9/phosphoproteomics identifies multiple noncanonical targets of myosin light chain kinase

Prior studies have implicated myosin light chain kinase (MLCK) in the regulation of aquaporin-2 (AQP2) in the renal collecting duct. To discover signaling targets of MLCK, we used CRISPR-Cas9 to delete the MLCK gene (Mylk) to obtain MLCK-null mpkCCD cells and carried out comprehensive phosphoproteom...

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Pubblicato in:Am J Physiol Renal Physiol
Autori principali: Isobe, Kiyoshi, Raghuram, Viswanathan, Krishnan, Laya, Chou, Chung-Lin, Yang, Chin-Rang, Knepper, Mark A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7099502/
https://ncbi.nlm.nih.gov/pubmed/31904282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00431.2019
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