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p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake

Cancer cells heavily depend on the amino acid glutamine to meet the demands associated with growth and proliferation. Due to the rapid consumption of glutamine, cancer cells frequently undergo glutamine starvation in vivo. We and others have shown that p53 is a critical regulator in metabolic stress...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Lowman, Xazmin H., Hanse, Eric A., Yang, Ying, Ishak Gabra, Mari B., Tran, Thai Q., Li, Haiqing, Kong, Mei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510239/
https://ncbi.nlm.nih.gov/pubmed/30865893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.02.037
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