p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake

Cancer cells heavily depend on the amino acid glutamine to meet the demands associated with growth and proliferation. Due to the rapid consumption of glutamine, cancer cells frequently undergo glutamine starvation in vivo. We and others have shown that p53 is a critical regulator in metabolic stress...

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Foilsithe in:Cell Rep
Main Authors: Lowman, Xazmin H., Hanse, Eric A., Yang, Ying, Ishak Gabra, Mari B., Tran, Thai Q., Li, Haiqing, Kong, Mei
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510239/
https://ncbi.nlm.nih.gov/pubmed/30865893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.02.037
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