Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation

The proton-coupled folate transporter (PCFT) mediates intestinal absorption of folates and their transport from blood to cerebrospinal fluid across the choroid plexus. Substitutions at Asp-109 in the first intracellular loop between the first and second transmembrane domains (TMDs) abolish PCFT func...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Aluri, Srinivas, Zhao, Rongbao, Lin, Kai, Shin, Daniel Sanghoon, Fiser, Andras, Goldman, I. David
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509503/
https://ncbi.nlm.nih.gov/pubmed/30858177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005533
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