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Rational Optimization of Conformational Effects Induced By Hydrocarbon Staples in Peptides and their Binding Interfaces

eIF4E is frequently over-expressed in different cancers and causes increased translation of oncogenic proteins via deregulated cap-dependent translation. Inhibitors of the eIF4E:eIF4G interactions represent an approach that would normalize cap-dependent translation. Stapled peptides represent an eme...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Lama, Dilraj, Quah, Soo T., Verma, Chandra S., Lakshminarayanan, Rajamani, Beuerman, Roger W., Lane, David P., Brown, Christopher J.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506440/
https://ncbi.nlm.nih.gov/pubmed/24336354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03451
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