Rational Optimization of Conformational Effects Induced By Hydrocarbon Staples in Peptides and their Binding Interfaces

eIF4E is frequently over-expressed in different cancers and causes increased translation of oncogenic proteins via deregulated cap-dependent translation. Inhibitors of the eIF4E:eIF4G interactions represent an approach that would normalize cap-dependent translation. Stapled peptides represent an eme...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Lama, Dilraj, Quah, Soo T., Verma, Chandra S., Lakshminarayanan, Rajamani, Beuerman, Roger W., Lane, David P., Brown, Christopher J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506440/
https://ncbi.nlm.nih.gov/pubmed/24336354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03451
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