Rational Optimization of Conformational Effects Induced By Hydrocarbon Staples in Peptides and their Binding Interfaces

eIF4E is frequently over-expressed in different cancers and causes increased translation of oncogenic proteins via deregulated cap-dependent translation. Inhibitors of the eIF4E:eIF4G interactions represent an approach that would normalize cap-dependent translation. Stapled peptides represent an eme...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Lama, Dilraj, Quah, Soo T., Verma, Chandra S., Lakshminarayanan, Rajamani, Beuerman, Roger W., Lane, David P., Brown, Christopher J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506440/
https://ncbi.nlm.nih.gov/pubmed/24336354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03451
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker