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Avoiding drug resistance through extended drug target interfaces: a case for stapled peptides

Cancer drugs often fail due to the emergence of clinical resistance. This can manifest through mutations in target proteins that selectively exclude drug binding whilst retaining aberrant function. A priori knowledge of resistance-inducing mutations is therefore important for both drug design and cl...

詳細記述

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書誌詳細
出版年:Oncotarget
主要な著者: Wei, Siau Jia, Chee, Sharon, Yurlova, Larisa, Lane, David, Verma, Chandra, Brown, Christopher, Ghadessy, Farid
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078010/
https://ncbi.nlm.nih.gov/pubmed/27057630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8572
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