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Avoiding drug resistance through extended drug target interfaces: a case for stapled peptides
Cancer drugs often fail due to the emergence of clinical resistance. This can manifest through mutations in target proteins that selectively exclude drug binding whilst retaining aberrant function. A priori knowledge of resistance-inducing mutations is therefore important for both drug design and cl...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5078010/ https://ncbi.nlm.nih.gov/pubmed/27057630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8572 |
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