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Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids
As primary p53 antagonists, Mdm2 and the closely related Mdm4 are relevant cancer therapeutic targets. We have previously described a series of cell-permeable stapled peptides that bind to Mdm2 with high affinity, resulting in activation of the p53 tumour suppressor. Within this series, highest affi...
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| Vydáno v: | PLoS One |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5724825/ https://ncbi.nlm.nih.gov/pubmed/29228061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189379 |
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