Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids

As primary p53 antagonists, Mdm2 and the closely related Mdm4 are relevant cancer therapeutic targets. We have previously described a series of cell-permeable stapled peptides that bind to Mdm2 with high affinity, resulting in activation of the p53 tumour suppressor. Within this series, highest affi...

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Pubblicato in:PLoS One
Autori principali: Chee, Sharon Min Qi, Wongsantichon, Jantana, Siau, Jiawei, Thean, Dawn, Ferrer, Fernando, Robinson, Robert C., Lane, David P., Brown, Christopher J., Ghadessy, Farid J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724825/
https://ncbi.nlm.nih.gov/pubmed/29228061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189379
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