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Soluble expression of proteins correlates with a lack of positively-charged surface

Prediction of protein solubility is gaining importance with the growing use of protein molecules as therapeutics, and ongoing requirements for high level expression. We have investigated protein surface features that correlate with insolubility. Non-polar surface patches associate to some degree wit...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Chan, Pedro, Curtis, Robin A., Warwicker, Jim
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506438/
https://ncbi.nlm.nih.gov/pubmed/24276756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03333
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