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Soluble expression of proteins correlates with a lack of positively-charged surface

Prediction of protein solubility is gaining importance with the growing use of protein molecules as therapeutics, and ongoing requirements for high level expression. We have investigated protein surface features that correlate with insolubility. Non-polar surface patches associate to some degree wit...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Chan, Pedro, Curtis, Robin A., Warwicker, Jim
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506438/
https://ncbi.nlm.nih.gov/pubmed/24276756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03333
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