Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D

Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human metaphase chromosomes under replication stress and are often deleted in cancer cells. We studied an ~300-bp subregion (Flex1) of human CFS FRA16D in yeast and found that it recapitulates characteristics of CFS frag...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Kaushal, Simran, Wollmuth, Charles E., Das, Kohal, Hile, Suzanne E., Regan, Samantha B., Barnes, Ryan P., Haouzi, Alice, Lee, Soo Mi, House, Nealia C.M., Guyumdzhyan, Michael, Eckert, Kristin A., Freudenreich, Catherine H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506224/
https://ncbi.nlm.nih.gov/pubmed/31018130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.03.103
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