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An AT-rich Sequence in Human Common Fragile Site FRA16D Causes Fork Stalling and Chromosome Breakage in S. cerevisiae

Common fragile sites are regions of human chromosomes prone to breakage. Fragile site FRA16D spans the WWOX/FOR tumor suppressor gene and has been linked to cancer-causing deletions and translocations. Using a genetic assay in yeast, we found that a short AT-rich region (Flex1) within FRA16D increas...

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Bibliografske podrobnosti
Main Authors: Zhang, Haihua, Freudenreich, Catherine H.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144737/
https://ncbi.nlm.nih.gov/pubmed/17679088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.06.012
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