Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D

Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human metaphase chromosomes under replication stress and are often deleted in cancer cells. We studied an ~300-bp subregion (Flex1) of human CFS FRA16D in yeast and found that it recapitulates characteristics of CFS frag...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Kaushal, Simran, Wollmuth, Charles E., Das, Kohal, Hile, Suzanne E., Regan, Samantha B., Barnes, Ryan P., Haouzi, Alice, Lee, Soo Mi, House, Nealia C.M., Guyumdzhyan, Michael, Eckert, Kristin A., Freudenreich, Catherine H.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506224/
https://ncbi.nlm.nih.gov/pubmed/31018130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.03.103
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker