Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D

Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human metaphase chromosomes under replication stress and are often deleted in cancer cells. We studied an ~300-bp subregion (Flex1) of human CFS FRA16D in yeast and found that it recapitulates characteristics of CFS frag...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Rep
Egile Nagusiak: Kaushal, Simran, Wollmuth, Charles E., Das, Kohal, Hile, Suzanne E., Regan, Samantha B., Barnes, Ryan P., Haouzi, Alice, Lee, Soo Mi, House, Nealia C.M., Guyumdzhyan, Michael, Eckert, Kristin A., Freudenreich, Catherine H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506224/
https://ncbi.nlm.nih.gov/pubmed/31018130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.03.103
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