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DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNA

Persistent hepatitis B virus (HBV) infection relies on the establishment and maintenance of covalently closed circular (ccc) DNA, a 3.2 kb episome that serves as a viral transcription template, in the nucleus of an infected hepatocyte. Although evidence suggests that cccDNA is the repair product of...

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Dettagli Bibliografici
Pubblicato in:PLoS Pathog
Autori principali: Tang, Liudi, Sheraz, Muhammad, McGrane, Michael, Chang, Jinhong, Guo, Ju-Tao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505960/
https://ncbi.nlm.nih.gov/pubmed/31026293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007742
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