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DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNA
Persistent hepatitis B virus (HBV) infection relies on the establishment and maintenance of covalently closed circular (ccc) DNA, a 3.2 kb episome that serves as a viral transcription template, in the nucleus of an infected hepatocyte. Although evidence suggests that cccDNA is the repair product of...
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| Veröffentlicht in: | PLoS Pathog |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6505960/ https://ncbi.nlm.nih.gov/pubmed/31026293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007742 |
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