Cellular DNA Topoisomerases Are Required for the Synthesis of Hepatitis B Virus Covalently Closed Circular DNA

In order to identify host cellular DNA metabolic enzymes that are involved in the biosynthesis of hepatitis B virus (HBV) covalently closed circular (ccc) DNA, we developed a cell-based assay supporting synchronized and rapid cccDNA synthesis from intracellular progeny nucleocapsid DNA. This was ach...

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Bibliographic Details
Published in:J Virol
Main Authors: Sheraz, Muhammad, Cheng, Junjun, Tang, Liudi, Chang, Jinhong, Guo, Ju-Tao
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532102/
https://ncbi.nlm.nih.gov/pubmed/30867306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02230-18
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