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Brain activity associated with pain in inherited erythromelalgia: stimulus-free pain engages brain areas involved in valuation and learning

Inherited erythromelalgia (IEM) is a chronic pain disorder caused by gain-of-function mutations of peripheral sodium channel Nav1.7, in which warmth triggers severe pain. Little is known about the brain representation of pain in IEM. Here we study two subjects with the IEM Nav1.7-S241T mutation usin...

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Bibliografiske detaljer
Udgivet i:Neurobiol Pain
Main Authors: Geha, Paul, Schulman, Betsy R., Dib-Hajj, Sulayman D., Waxman, Stephen G.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505710/
https://ncbi.nlm.nih.gov/pubmed/31080911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ynpai.2018.01.002
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