Nav1.7-A1632G Mutation from a Family with Inherited Erythromelalgia: Enhanced Firing of Dorsal Root Ganglia Neurons Evoked by Thermal Stimuli

Voltage-gated sodium channel Nav1.7 is a central player in human pain. Mutations in Nav1.7 produce several pain syndromes, including inherited erythromelalgia (IEM), a disorder in which gain-of-function mutations render dorsal root ganglia (DRG) neurons hyperexcitable. Although patients with IEM suf...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Yang, Yang, Huang, Jianying, Mis, Malgorzata A., Estacion, Mark, Macala, Lawrence, Shah, Palak, Schulman, Betsy R., Horton, Daniel B., Dib-Hajj, Sulayman D., Waxman, Stephen G.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705539/
https://ncbi.nlm.nih.gov/pubmed/27413160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0462-16.2016
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