Caspase-1 initiates apoptosis in the absence of gasdermin D

Caspase-1 activated in inflammasomes triggers a programmed necrosis called pyroptosis, which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still susceptible to caspase-1-mediated cell death. Therefore, here, we investigate the mechanism of caspase-1-initiated cell death in G...

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Pubblicato in:Nat Commun
Autori principali: Tsuchiya, Kohsuke, Nakajima, Shinsuke, Hosojima, Shoko, Thi Nguyen, Dinh, Hattori, Tsuyoshi, Manh Le, Thuong, Hori, Osamu, Mahib, Mamunur Rashid, Yamaguchi, Yoshifumi, Miura, Masayuki, Kinoshita, Takeshi, Kushiyama, Hiroko, Sakurai, Mayumi, Shiroishi, Toshihiko, Suda, Takashi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505044/
https://ncbi.nlm.nih.gov/pubmed/31064994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09753-2
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