CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes

Oligodendrocytes (OLs) support neurons and signal transmission in the central nervous system (CNS) by enwrapping axons with myelin, a lipid-rich membrane structure. We addressed the significance of fatty acid (FA) synthesis in OLs by depleting FA synthase (FASN) from OL progenitor cells (OPCs) in tr...

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Publicado en:eLife
Autores principales: Dimas, Penelope, Montani, Laura, Pereira, Jorge A, Moreno, Daniel, Trötzmüller, Martin, Gerber, Joanne, Semenkovich, Clay F, Köfeler, Harald C, Suter, Ueli
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504237/
https://ncbi.nlm.nih.gov/pubmed/31063129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44702
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