De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination

Myelination calls for a remarkable surge in cell metabolism to facilitate lipid and membrane production. Endogenous fatty acid (FA) synthesis represents a potentially critical process in myelinating glia. Using genetically modified mice, we show that Schwann cell (SC) intrinsic activity of the enzym...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Montani, Laura, Pereira, Jorge A., Norrmén, Camilla, Pohl, Hartmut B.F., Tinelli, Elisa, Trötzmüller, Martin, Figlia, Gianluca, Dimas, Penelope, von Niederhäusern, Belinda, Schwager, Rachel, Jessberger, Sebastian, Semenkovich, Clay F., Köfeler, Harald C., Suter, Ueli
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881495/
https://ncbi.nlm.nih.gov/pubmed/29434029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201706010
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