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Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
Myelination is a biosynthetically demanding process in which mTORC1, the gatekeeper of anabolism, occupies a privileged regulatory position. We have shown previously that loss of mTORC1 function in Schwann cells (SCs) hampers myelination. Here, we genetically disrupted key inhibitory components upst...
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| Publicat a: | eLife |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
eLife Sciences Publications, Ltd
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5589416/ https://ncbi.nlm.nih.gov/pubmed/28880149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29241 |
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