De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination

Myelination calls for a remarkable surge in cell metabolism to facilitate lipid and membrane production. Endogenous fatty acid (FA) synthesis represents a potentially critical process in myelinating glia. Using genetically modified mice, we show that Schwann cell (SC) intrinsic activity of the enzym...

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Publicado en:J Cell Biol
Autores principales: Montani, Laura, Pereira, Jorge A., Norrmén, Camilla, Pohl, Hartmut B.F., Tinelli, Elisa, Trötzmüller, Martin, Figlia, Gianluca, Dimas, Penelope, von Niederhäusern, Belinda, Schwager, Rachel, Jessberger, Sebastian, Semenkovich, Clay F., Köfeler, Harald C., Suter, Ueli
Formato: Artigo
Lenguaje:Inglês
Publicado: Rockefeller University Press 2018
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881495/
https://ncbi.nlm.nih.gov/pubmed/29434029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201706010
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