PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastoma

Glioblastoma (GBM) is the most malignant brain tumor with profound genomic alterations. Tumor suppressor genes regulate multiple signaling networks that restrict cellular proliferation and present barriers to malignant transformation. While bona fide tumor suppressors such as PTEN and TP53 often und...

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Vydáno v:J Exp Med
Hlavní autoři: Shin, Yong Jae, Sa, Jason K., Lee, Yeri, Kim, Donggeon, Chang, Nakho, Cho, Hee Jin, Son, Miseol, Oh, Michael Y.T., Shin, Kayoung, Lee, Jin-Ku, Park, Jiwon, Jo, Yoon Kyung, Kim, Misuk, Paddison, Patrick J., Tergaonkar, Vinay, Lee, Jeongwu, Nam, Do-Hyun
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504209/
https://ncbi.nlm.nih.gov/pubmed/30898893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20172170
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