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Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS
Cellular innate immune sensors of DNA are essential for host defense against invading pathogens. However, the presence of self-DNA inside cells poses a risk of triggering unchecked immune responses. The mechanisms limiting induction of inflammation by self-DNA are poorly understood. BLM RecQ–like he...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Exp Med |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Rockefeller University Press
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6504208/ https://ncbi.nlm.nih.gov/pubmed/30936263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181329 |
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