Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS

Cellular innate immune sensors of DNA are essential for host defense against invading pathogens. However, the presence of self-DNA inside cells poses a risk of triggering unchecked immune responses. The mechanisms limiting induction of inflammation by self-DNA are poorly understood. BLM RecQ–like he...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Exp Med
Auteurs principaux: Gratia, Matthieu, Rodero, Mathieu P., Conrad, Cécile, Bou Samra, Elias, Maurin, Mathieu, Rice, Gillian I., Duffy, Darragh, Revy, Patrick, Petit, Florence, Dale, Russell C., Crow, Yanick J., Amor-Gueret, Mounira, Manel, Nicolas
Format: Artigo
Langue:Inglês
Publié: Rockefeller University Press 2019
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504208/
https://ncbi.nlm.nih.gov/pubmed/30936263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181329
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