Emergence and functional fitness of memory CD4(+) T cells require the transcription factor Thpok

Memory CD4(+) T cells mediate long term immunity, and their generation is a key objective of vaccination strategies. However, the transcriptional circuitry controlling the emergence of memory cells from early CD4(+) antigen-responders remains poorly understood. Here, using single-cell RNAseq to stud...

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Veröffentlicht in:Immunity
Hauptverfasser: Ciucci, Thomas, Vacchio, Melanie S., Gao, Yayi, Ardori, Francesco Tomassoni, Candia, Julian, Mehta, Monika, Zhao, Yongmei, Tran, Bao, Pepper, Marion, Tessarollo, Lino, McGavern, Dorian B., Bosselut, Rémy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503975/
https://ncbi.nlm.nih.gov/pubmed/30638736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.12.019
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