Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence

Most human pre-mRNA transcripts are alternatively spliced, but the significance and fine-tuning of alternative splicing in different biological processes is only starting to be understood. SRSF3 (SRp20) is a member of a highly conserved family of splicing factors that have critical roles in key biol...

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Gepubliceerd in:Oncogene
Hoofdauteurs: Tang, Y, Horikawa, I, Ajiro, M, Robles, Al, Fujita, K, Mondal, AM, Stauffer, JK, Zheng, Z-M, Harris, CC
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503963/
https://ncbi.nlm.nih.gov/pubmed/22777358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.288
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