Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking

Chemical probes of epigenetic ‘readers’ of histone posttranslational modifications (PTMs) have become powerful tools for mechanistic and functional studies of their target proteins in normal physiology and disease pathogenesis. Here we report the development of the first class of chemical probes of...

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Vydáno v:Nat Chem Biol
Hlavní autoři: Li, Xin, Li, Xiao-Meng, Jiang, Yixiang, Liu, Zheng, Cui, Yiwen, Fung, Ka Yi, van der Beelen, Stan H. E., Tian, Gaofei, Wan, Liling, Shi, Xiaobing, Allis, C. David, Li, Haitao, Li, Yuanyuan, Li, Xiang David
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503841/
https://ncbi.nlm.nih.gov/pubmed/30374167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0144-y
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