Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking

Chemical probes of epigenetic ‘readers’ of histone posttranslational modifications (PTMs) have become powerful tools for mechanistic and functional studies of their target proteins in normal physiology and disease pathogenesis. Here we report the development of the first class of chemical probes of...

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Publicado no:Nat Chem Biol
Main Authors: Li, Xin, Li, Xiao-Meng, Jiang, Yixiang, Liu, Zheng, Cui, Yiwen, Fung, Ka Yi, van der Beelen, Stan H. E., Tian, Gaofei, Wan, Liling, Shi, Xiaobing, Allis, C. David, Li, Haitao, Li, Yuanyuan, Li, Xiang David
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503841/
https://ncbi.nlm.nih.gov/pubmed/30374167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0144-y
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