Structural insights into the π-π-π stacking mechanism and DNA-binding activity of the YEATS domain

The YEATS domain has been identified as a reader of histone acylation and more recently emerged as a promising anti-cancer therapeutic target. Here, we detail the structural mechanisms for π-π-π stacking involving the YEATS domains of yeast Taf14 and human AF9 and acylated histone H3 peptides and ex...

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Pubblicato in:Nat Commun
Autori principali: Klein, Brianna J., Vann, Kendra R., Andrews, Forest H., Wang, Wesley W., Zhang, Jibo, Zhang, Yi, Beloglazkina, Anastasia A., Mi, Wenyi, Li, Yuanyuan, Li, Haitao, Shi, Xiaobing, Kutateladze, Andrei G., Strahl, Brian D., Liu, Wenshe R., Kutateladze, Tatiana G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212594/
https://ncbi.nlm.nih.gov/pubmed/30385749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07072-6
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