Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection

Norovirus infection is the leading cause of food-borne gastroenteritis worldwide, being responsible for over 200,000 deaths annually. Studies with murine norovirus (MNV) showed that protective STAT1 signaling controls viral replication and pathogenesis, but the immune mechanisms that noroviruses exp...

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Publicat a:PLoS Pathog
Autors principals: Dubois, Hanne, Sorgeloos, Frederic, Sarvestani, Soroush T., Martens, Liesbet, Saeys, Yvan, Mackenzie, Jason M., Lamkanfi, Mohamed, van Loo, Geert, Goodfellow, Ian, Wullaert, Andy
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502405/
https://ncbi.nlm.nih.gov/pubmed/31017981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007709
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