Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection

Norovirus infection is the leading cause of food-borne gastroenteritis worldwide, being responsible for over 200,000 deaths annually. Studies with murine norovirus (MNV) showed that protective STAT1 signaling controls viral replication and pathogenesis, but the immune mechanisms that noroviruses exp...

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Vydáno v:PLoS Pathog
Hlavní autoři: Dubois, Hanne, Sorgeloos, Frederic, Sarvestani, Soroush T., Martens, Liesbet, Saeys, Yvan, Mackenzie, Jason M., Lamkanfi, Mohamed, van Loo, Geert, Goodfellow, Ian, Wullaert, Andy
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502405/
https://ncbi.nlm.nih.gov/pubmed/31017981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007709
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