Indoxyl Sulfate Induces Renal Fibroblast Activation through a Targetable Heat Shock Protein 90-Dependent Pathway

Indoxyl sulfate (IS) accumulation occurs early during chronic kidney disease (CKD) progression and contributes to renal dysfunction by inducing fibrosis, inflammation, oxidative stress, and tissue remodeling. Renal toxicity of high IS concentrations (250 μM) has been widely explored, particularly in...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Milanesi, Samantha, Garibaldi, Silvano, Saio, Michela, Ghigliotti, Giorgio, Picciotto, Daniela, Ameri, Pietro, Garibotto, Giacomo, Barisione, Chiara, Verzola, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6501427/
https://ncbi.nlm.nih.gov/pubmed/31178953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/2050183
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados