Moderate Increase of Indoxyl Sulfate Promotes Monocyte Transition into Profibrotic Macrophages

OBJECTIVE: The uremic toxin Indoxyl-3-sulphate (IS), a ligand of Aryl hydrocarbon Receptor (AhR), raises in blood during early renal dysfunction as a consequence of tubular damage, which may be present even when eGFR is normal or only moderately reduced, and promotes cardiovascular damage and monocy...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Barisione, Chiara, Garibaldi, Silvano, Furfaro, Anna Lisa, Nitti, Mariapaola, Palmieri, Daniela, Passalacqua, Mario, Garuti, Anna, Verzola, Daniela, Parodi, Alessia, Ameri, Pietro, Altieri, Paola, Fabbi, Patrizia, Ferrar, Pier Francesco, Brunelli, Claudio, Arsenescu, Violeta, Balbi, Manrico, Palombo, Domenico, Ghigliotti, Giorgio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771744/
https://ncbi.nlm.nih.gov/pubmed/26925780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149276
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