Indoxyl Sulfate Induces Renal Fibroblast Activation through a Targetable Heat Shock Protein 90-Dependent Pathway

Indoxyl sulfate (IS) accumulation occurs early during chronic kidney disease (CKD) progression and contributes to renal dysfunction by inducing fibrosis, inflammation, oxidative stress, and tissue remodeling. Renal toxicity of high IS concentrations (250 μM) has been widely explored, particularly in...

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Bibliografski detalji
Izdano u:Oxid Med Cell Longev
Glavni autori: Milanesi, Samantha, Garibaldi, Silvano, Saio, Michela, Ghigliotti, Giorgio, Picciotto, Daniela, Ameri, Pietro, Garibotto, Giacomo, Barisione, Chiara, Verzola, Daniela
Format: Artigo
Jezik:Inglês
Izdano: Hindawi 2019
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6501427/
https://ncbi.nlm.nih.gov/pubmed/31178953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/2050183
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