Enhanced myostatin expression and signalling promote tubulointerstitial inflammation in diabetic nephropathy

Myostatin (MSTN), a family member of the transforming growth factor (TGF)-β super family, has been detected in the tubuli of pig kidney, but its role in the human kidney is not known. In this study we observed upregulation of MSTN mRNA (~8 to 10-fold increase) both in the glomeruli and tubulointerst...

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Vydáno v:Sci Rep
Hlavní autoři: Verzola, Daniela, Milanesi, Samantha, Viazzi, Francesca, Ansaldo, Francesca, Saio, Michela, Garibaldi, Silvano, Carta, Annalisa, Costigliolo, Francesca, Salvidio, Gennaro, Barisione, Chiara, Esposito, Pasquale, Garibotto, Giacomo, Picciotto, Daniela
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156449/
https://ncbi.nlm.nih.gov/pubmed/32286342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62875-2
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