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Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells

BACKGROUND: DNA methyltransferases (DNMTs) are epigenetic enzymes involved in embryonic development, cell differentiation, epithelial to mesenchymal transition, and control of gene expression, whose overexpression or enhanced catalytic activity has been widely reported in cancer initiation and progr...

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書誌詳細
出版年:Clin Epigenetics
主要な著者: Zwergel, Clemens, Schnekenburger, Michael, Sarno, Federica, Battistelli, Cecilia, Manara, Maria Cristina, Stazi, Giulia, Mazzone, Roberta, Fioravanti, Rossella, Gros, Christina, Ausseil, Frédéric, Florean, Cristina, Nebbioso, Angela, Strippoli, Raffaele, Ushijima, Toshikazu, Scotlandi, Katia, Tripodi, Marco, Arimondo, Paola B., Altucci, Lucia, Diederich, Marc, Mai, Antonello, Valente, Sergio
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6501426/
https://ncbi.nlm.nih.gov/pubmed/31060628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0663-8
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