Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells

BACKGROUND: DNA methyltransferases (DNMTs) are epigenetic enzymes involved in embryonic development, cell differentiation, epithelial to mesenchymal transition, and control of gene expression, whose overexpression or enhanced catalytic activity has been widely reported in cancer initiation and progr...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Zwergel, Clemens, Schnekenburger, Michael, Sarno, Federica, Battistelli, Cecilia, Manara, Maria Cristina, Stazi, Giulia, Mazzone, Roberta, Fioravanti, Rossella, Gros, Christina, Ausseil, Frédéric, Florean, Cristina, Nebbioso, Angela, Strippoli, Raffaele, Ushijima, Toshikazu, Scotlandi, Katia, Tripodi, Marco, Arimondo, Paola B., Altucci, Lucia, Diederich, Marc, Mai, Antonello, Valente, Sergio
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6501426/
https://ncbi.nlm.nih.gov/pubmed/31060628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0663-8
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