Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation

DNA methyltransferases (DNMTs) play a relevant role in epigenetic control of cancer cell survival and proliferation. Since only two DNMT inhibitors (azacitidine and decitabine) have been approved to date for the treatment of hematological malignancies, the development of novel potent and specific in...

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Publicado no:Cancers (Basel)
Main Authors: Zwergel, Clemens, Fioravanti, Rossella, Stazi, Giulia, Sarno, Federica, Battistelli, Cecilia, Romanelli, Annalisa, Nebbioso, Angela, Mendes, Eduarda, Paulo, Alexandra, Strippoli, Raffaele, Tripodi, Marco, Pechalrieu, Dany, Arimondo, Paola B., De Luca, Teresa, Del Bufalo, Donatella, Trisciuoglio, Daniela, Altucci, Lucia, Valente, Sergio, Mai, Antonello
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073229/
https://ncbi.nlm.nih.gov/pubmed/32075099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12020447
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