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DOT1L: a key target in normal chromatin remodelling and in mixed-lineage leukaemia treatment

Methylation of histone 3 at lysine 79 (H3K79) is one of the principal mechanisms involved in gene expression. The histone methyltransferase DOT1L, which mono-, di- and trimethylates H3K79 using S-adenosyl-L-methionine as a co-factor, is involved in cell development, cell cycle progression, and DNA d...

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Bibliografiske detaljer
Udgivet i:Epigenetics
Main Authors: Sarno, Federica, Nebbioso, Angela, Altucci, Lucia
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188393/
https://ncbi.nlm.nih.gov/pubmed/31790636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2019.1699991
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