New Insights on the Mechanism of Quinoline-based DNA Methyltransferase Inhibitors

Among the epigenetic marks, DNA methylation is one of the most studied. It is highly deregulated in numerous diseases, including cancer. Indeed, it has been shown that hypermethylation of tumor suppressor genes promoters is a common feature of cancer cells. Because DNA methylation is reversible, the...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Gros, Christina, Fleury, Laurence, Nahoum, Virginie, Faux, Céline, Valente, Sergio, Labella, Donatella, Cantagrel, Frédéric, Rilova, Elodie, Bouhlel, Mohamed Amine, David-Cordonnier, Marie-Hélène, Dufau, Isabelle, Ausseil, Frédéric, Mai, Antonello, Mourey, Lionel, Lacroix, Laurent, Arimondo, Paola B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Gene Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358266/
https://ncbi.nlm.nih.gov/pubmed/25525263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.594671
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