Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation

BACKGROUND AND OBJECTIVE: Progressive pulmonary fibrosis is the main cause of death in patients with systemic sclerosis (SSc) with interstitial lung disease (ILD) and in those with idiopathic pulmonary fibrosis (IPF). Transforming growth factor-β (TGF-β) and NADPH oxidase- (NOX-) derived reactive ox...

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Bibliographic Details
Published in:Biomed Res Int
Main Authors: Stock, Carmel J. W., Michaeloudes, Charalambos, Leoni, Patricia, Durham, Andrew L., Mumby, Sharon, Wells, Athol U., Chung, Kian Fan, Adcock, Ian M., Renzoni, Elisabetta A., Lindahl, Gisela E.
Format: Artigo
Language:Inglês
Published: Hindawi 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500679/
https://ncbi.nlm.nih.gov/pubmed/31119153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/1484736
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