Bromodomain and Extraterminal (BET) Proteins Regulate Hepatocyte Proliferation in Hepatocyte-Driven Liver Regeneration

Bromodomain and extraterminal (BET) proteins recruit key components of basic transcriptional machinery to promote gene expression. Aberrant expression and mutations in BET genes have been identified in many malignancies. Small molecule inhibitors of BET proteins such as JQ1 have shown efficacy in pr...

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Veröffentlicht in:Am J Pathol
Hauptverfasser: Russell, Jacquelyn O., Ko, Sungjin, Saggi, Harvinder S., Singh, Sucha, Poddar, Minakshi, Shin, Donghun, Monga, Satdarshan P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971221/
https://ncbi.nlm.nih.gov/pubmed/29545201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.02.006
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