Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation

BACKGROUND AND OBJECTIVE: Progressive pulmonary fibrosis is the main cause of death in patients with systemic sclerosis (SSc) with interstitial lung disease (ILD) and in those with idiopathic pulmonary fibrosis (IPF). Transforming growth factor-β (TGF-β) and NADPH oxidase- (NOX-) derived reactive ox...

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Publicado en:Biomed Res Int
Main Authors: Stock, Carmel J. W., Michaeloudes, Charalambos, Leoni, Patricia, Durham, Andrew L., Mumby, Sharon, Wells, Athol U., Chung, Kian Fan, Adcock, Ian M., Renzoni, Elisabetta A., Lindahl, Gisela E.
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500679/
https://ncbi.nlm.nih.gov/pubmed/31119153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/1484736
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