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Histone deacetylase inhibitors reduce polyglutamine toxicity
Polyglutamine diseases include at least nine neurodegenerative disorders, each caused by a CAG repeat expansion in a different gene. Accumulation of mutant polyglutamine-containing proteins occurs in patients, and evidence from cell culture and animal experiments suggests the nucleus as a site of pa...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The National Academy of Sciences
2001
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC65003/ https://ncbi.nlm.nih.gov/pubmed/11742087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.261400698 |
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