Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein

Sequestration of the transcriptional coactivator CREB-binding protein (CBP), a histone acetyltransferase, has been implicated in the pathogenesis of polyglutamine expansion neurodegenerative disease. We used a Drosophila model to demonstrate that polyglutamine-induced neurodegeneration is accompanie...

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Detalhes bibliográficos
Main Authors: Taylor, J. Paul, Taye, Addis A., Campbell, Catherine, Kazemi-Esfarjani, Parsa, Fischbeck, Kenneth H., Min, Kyung-Tai
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196076/
https://ncbi.nlm.nih.gov/pubmed/12815067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1087503
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