HISTONE ACETYLATION, ACETYLTRANSFERASES, AND ATAXIA—ALTERATION OF HISTONE ACETYLATION AND CHROMATIN DYNAMICS IS IMPLICATED IN THE PATHOGENESIS OF POLYGLUTAMINE-EXPANSION DISORDERS

Eukaryotic chromosomal DNA is packaged into nucleosomes to form a dynamic structure known as chromatin. The compaction of DNA within chromatin poses a unique hindrance with regards to the accessibility of the DNA to enzymes involved in replication, transcriptional regulation, and repair. The physica...

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Detaylı Bibliyografya
Asıl Yazarlar: McCULLOUGH, SHAUN D., GRANT, PATRICK A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964930/
https://ncbi.nlm.nih.gov/pubmed/20621284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1876-1623(10)79005-2
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