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HISTONE ACETYLATION, ACETYLTRANSFERASES, AND ATAXIA—ALTERATION OF HISTONE ACETYLATION AND CHROMATIN DYNAMICS IS IMPLICATED IN THE PATHOGENESIS OF POLYGLUTAMINE-EXPANSION DISORDERS
Eukaryotic chromosomal DNA is packaged into nucleosomes to form a dynamic structure known as chromatin. The compaction of DNA within chromatin poses a unique hindrance with regards to the accessibility of the DNA to enzymes involved in replication, transcriptional regulation, and repair. The physica...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2964930/ https://ncbi.nlm.nih.gov/pubmed/20621284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1876-1623(10)79005-2 |
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