Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration

Spinocerebellar ataxia type 7 (SCA7) is characterized by cone-rod dystrophy retinal degeneration and is caused by a polyglutamine [poly(Q)] expansion within ataxin-7, a protein of previously unknown function. Here, we report that ataxin-7 is an integral component of the mammalian STAGA (SPT3-TAF9-AD...

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Detalhes bibliográficos
Main Authors: Palhan, Vikas B., Chen, Shiming, Peng, Guang-Hua, Tjernberg, Agneta, Gamper, Armin M., Fan, Yuxin, Chait, Brian T., La Spada, Albert R., Roeder, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150862/
https://ncbi.nlm.nih.gov/pubmed/15932940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503505102
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