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Structural dynamics and transient lipid binding of synaptobrevin-2 tune SNARE assembly and membrane fusion

Intrinsically disordered proteins (IDPs) and their conformational transitions play an important role in neurotransmitter release at the neuronal synapse. Here, the SNARE proteins are essential by forming the SNARE complex that drives vesicular membrane fusion. While it is widely accepted that the SN...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lakomek, Nils-Alexander, Yavuz, Halenur, Jahn, Reinhard, Pérez-Lara, Ángel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500178/
https://ncbi.nlm.nih.gov/pubmed/30975750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813194116
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