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Structural dynamics and transient lipid binding of synaptobrevin-2 tune SNARE assembly and membrane fusion

Intrinsically disordered proteins (IDPs) and their conformational transitions play an important role in neurotransmitter release at the neuronal synapse. Here, the SNARE proteins are essential by forming the SNARE complex that drives vesicular membrane fusion. While it is widely accepted that the SN...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Lakomek, Nils-Alexander, Yavuz, Halenur, Jahn, Reinhard, Pérez-Lara, Ángel
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500178/
https://ncbi.nlm.nih.gov/pubmed/30975750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813194116
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